The cees dekker Diaries
The cees dekker Diaries
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Nanotechnology delivers A selection of opportunities to add to biology. Right here I will current illustrations where by nanofabrication – the ability to make confined buildings with Proportions at will – is used to look at the biophysics of single molecules and cells. I will current some illustrations from our lab:
Our team scientific tests bacterial cell division and it is aiming to represent a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in mobile division, chromatin construction, and spatial control.
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
Regrettably, for years soon after Iijima’s report, the production of clear nanotubes was cumbersome. In 1996, however, the group of Richard Smalley at Rice College managed to produce solitary-walled carbon nanotubes at superior yield. Shortly just after, I contacted Smalley, and we decided to be part of forces to evaluate the transport by way of a one carbon nanotube.
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Microbiology has only existed to get a century, since we began to examine micro-organisms additional very seriously. I believed nanobiology was an correct expression, because all molecular biological relevant interactions take place for the nanoscale: a protein is several nanometres in size, DNA is two nm thick.’
What distinguishes biology from chemistry is always that these factors jointly make up a dwelling technique. The secret of stated lifetime, I believe, lies inside the interactions, the interplay of People molecules. The massive dilemma regarding the origin of existence continues to be unanswered. How did we at any time evolve from basic molecules in the very complex programs we see now? We have no idea. I want to work on These types of big, open up concerns.’
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
In 1993, for a young and eager associate professor at Delft College of Technologies, I'd in the beginning targeted the research endeavours of my group on measuring the electrical conductance of only one conducting-polymer molecule. Within two several years, we experienced designed a tool during which an individual wire of the phthalocyaninepolysiloxane polymer was related involving two carefully spaced metallic nanoelectrodes.
‘The fantastically refined way during which factors in character perform by no means ceases to amaze me. If we solve the puzzle of how everyday living arrived into getting, I anticipate that my amazement at the complexity of generation could have improved ceesdekker and with it my awe for your greatness of your Creator.’
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
2001, discovery of one-electron transistors at home temperature based on nanotubes; realization of first logic circuits with carbon nanotube gadgets; and discovery from the molecular construction of DNA fix enzymes with AFM
Developments in nanotechnology within the nineties created constructing electronic units from solitary molecules a likelihood. Cees Dekker recounts how his crew designed a place-temperature transistor dependant on only one carbon nanotube.
2004, discovery of new physics in translocation of DNA by way of nanopores; first experimental review of ions conduction in nanofluidic channels; initially electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; very first electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization on the mechanical Homes of double-stranded RNA; and initially single-molecule study of DNA translocation by a restriction-modification enzyme.